Phase 3

 

Dans la Phase 3 en cours (2011-2015), les seuils de des réponses aigües systématiques chez l'humain exposé à un champ magnétique pouvant atteindre 50 mT aux fréquences domestiques (50 et 60 Hz) font l'objet d'une large étude menée sur des volontaires. Ce projet s'intéresse plus particulièrement à des marqueurs neurophysiologiques tels que la perception de magnétophosphènes et les réponses éléctroencéphalographiques (EEG). 

 

Articles

Legros A., Modolo J., Brown S., Robertson J., Thomas A. W. (2015) Effects of a 60 Hz magnetic field exposure up to 3000 µT on human brain activation as measured by functional magnetic resonance imaging. PlosOne, DOI: 10.1371/journal.pone.0132024. [PMCID: PMC4516358]


Modolo J., Legros A., Beuter A. (2014) The next move in neuromodulation therapy: a question of timing. Frontiers in Computational Neuroscience, 8:162. [PMCID: PMC4327509]


Souques M., Plante M., Ostiguy G., Goulet D., Deschamps F., Mezei G., Modolo J., Legros A. (2014) Anecdotal Report of Magnetophosphene Perception in Magnetic Fields of 50 mT at Frequencies of 20, 50 and 60 Hz / Rapport anectodique de la perception des magnétophophènes dans un champ magnétique de 50 mT à 20, 50 et 60 Hz. Radioprotection, 49 (1) 69-71. Abstract Available.


Legros A., Miller J., Modolo J., Corbacio M., Robertson J., Goulet D., Lambrozo J., Plante M., Souques M., Prato F.S., Thomas A.W. (2013) Efeitos de campos eletromagneticos no sistema nervoso humano. Electricidade Moderna, 475: 94-105.


Modolo J., Thomas A. W., Legros A. (2013) Neural mass modeling of power-line magnetic fields effects on brain activity. Frontiers in Computational Neuroscience, 7(34):1-15. doi:10.3389/fncom.2013.00034. Abstract Available


Modolo J., Thomas A. W., Legros A. (2013) Possible mechanisms of synaptic plasticity modulation by 60 Hz magnetic fields. Electromagnetic Biology and Medicine, 32(2):137-144. [PMID: 23675616]


Legros A., Corbacio M., Beuter A., Modolo J., Goulet J. Prato F. S., Thomas A. W. (2012) Neurophysiological and behavioral effects of a 60 Hz, 1800 microtesla magnetic field in humans. Eur J Appl Physiol 112:1751-1762. [PMID: 21894451]


Modolo J., Beuter A., Thomas A. W., Legros A. (2012) Using "smart stimulators" to treat Parkinson's disease: re-engineering neurostimulation devices. Frontiers in Computational Neuroscience, 6: 69. [PMID: 23060781]


Modolo J., Thomas A. W., Legros A. (2012) Possible mechanisms of synaptic plasticity modulation by 60 Hz magnetic fields. Electromagnetic Biology and Medicine, 32(2):137-144. doi:10.3109/15368378.2013.776341. Abstract Available


Corbacio M., Brown S., Dubois S., Beuter A., Prato F.S., Thomas A.W., Legros A. (2011) Human Cognitive Performance in a 3mT Power-Line Frequency Magnetic Field. Bioelectromagnetics, 32(8): 620-633. [PMID: 21544842]


Legros A., Miller J., Modolo J., Corbacio M., Robertson J., Goulet D., Lambrozo J., Plante M., Souques M., Prato F.S., Thomas A.W. (2011) Multi-modalities investigation of 60 Hz magnetic field effects on the human central nervous system. Electra, 256: 4-18.


Marshall H.R., Stodilka R.Z., Theberge J., Sabondjian E., Legros A., Deans L., Sykes J.M., Thompson R.T., Prato F.S. (2011) A comparison of MR-based attenuation correction in PET versus SPECT. Physics in Medicine and Biology, 56(14): 4613-29. [PMID: 21725141]


Modolo J., Legros A., Thomas A. W., Beuter A. (2011) Modeling-driven therapeutic treatment of neurological disorders: reshaping brain rhythms with neuromodulation, Interface Focus, 1(1): 61-74. [PMID: 22419974]


McNamee D., Corbacio M.A., Weller J.K., Brown S., Stodilka R.S., Prato F.S., Bureau Y., Thomas A.W., Legros A. (2011) The Response of the Human Circulatory System to an Acute 200 µT, 60 Hz Magnetic Field Exposure. Int Arch Occup Environ Health, 84(3): 267-277. [PMID: 20496180]


Robertson J. A., Thomas A. W., Modolo J., Miller J., Juen N., Legros A., Prato F. S. (2011) Evolution of Hybrid Functional Imaging in Bioelectromagnetics Research. Invited paper to a special issue of the Environmentalist, 31(2):134-139


Stodilka R.Z., Modolo J., Prato F.S., Robertson J.A., Cook C., Patrick J., Beuter A., Thomas A.W., Legros A. (2011) Pulsed magnetic field exposure induces lasting changes in neural network dynamics. Neurocomputing, 74(12-13): 2164-75.

 

 

Rapports

Legros A., Corbacio M., Villard S., Souques M., Lambrozo J. (2016) Acute Impact of Human Exposure to a Power-line Frequency Magnetic Field on Blood Biomarkers. 14 pgs. Final report for the Service des études Médicales (SEM) of EDF.


Legros A., Modolo J., Thomas A., (2014) Formal annual report at the annual meeting of our industrial partners (UTIC meeting involving Hydro-Québec, EDF, RTE, EPRI, National Grid) – Nice, France. Report given as a two different 2 hour platform presentations (113 slides and 73 slides respectively).


Legros A., Modolo J., Thomas A. (2013) Formal step report at the annual meeting of our industrial partners (UTIC meeting involving Hydro-Québec, EDF, RTE, EPRI, National Grid) – London, Ontario, Canada. Report given as a 2 hour platform presentation (97 slides).


Legros A., Modolo J., Thomas A. (2013) Threshold for a systematic human neurophysiological response to power line frequency magnetic field exposure - EPRI component: Effects of a 60Hz magnetic field of up to 50mT on human neuromotor control: an EEG/EMG/tremor study. Electric Power Research Institute.


Legros A., Thomas A. (2013) Effects of a power-line frequency magnetic field on human cognitive performances and brain activation which may be related to worker safety and performance, and other health-related concerns. Final electronic report for the CIHR, Operating Grant: Industry-partnered Collaborative Research.


Modolo J., Thomas A., Legros A. (2013) Development and validation of a mathematical model of brain activity during deep brain stimulation in Parkinson's disease. 24 pgs. MITACS Elevate Fellowship Scientific Final Report.


Modolo J., Thompson T., Legros A. (2013) Development and validation of a mathematical model of brain activity during deep brain stimulation in Parkinson's disease. 6 pgs. Administrative MITACS Elevate Final Report.


Modolo J., Thomas A., Legros A. (2012) Development and validation of a mathematical model of brain activity during deep brain stimulation in Parkinson's disease. 20 pgs. MITACS Elevate Fellowship Scientific Annual Report.


 

Conférences, Résumés et Proceedings

Legros A., Modolo J.,Corbacio M., Goulet D., Plante M., Souques M., Deschamps F., Ostiguy G., Lambrozo J., Thomas A. W. Magnetophosphene perception threshold in human exposed to Extremely Low Frequency magnetic fields of up to 50 mT. Annual Conference of the Canadian Radiation Protection Association, Toronto, May 17th – 20th, 2016


Legros A., Modolo J.,Corbacio M., Goulet D., Plante M., Souques M., Deschamps F., Ostiguy G., Lambrozo J., Thomas A. W. Threshold for an acute ELF-induced neurophysiological response in human – magnetophosphenes. 8th International NIR Workshop, Cape Town, May 9th - 11th, 2016


Legros A., Modolo J.,Corbacio M., Goulet D., Plante M., Souques M., Deschamps F., Ostiguy G., Lambrozo J., Thomas A. W. Magnetophospenes in humans exposed to ELF MF up to 50 mT, a threshold study. Annual Joint Meeting of the Bioelectromagnetics Society and the European BioElectromagnetics Association – BioEm2016, Ghent, Belgium, June 5th -10th, 2016


Legros A., Modolo J., Goulet D., Plante M., Souques M., Deschamps F., Ostiguy G., Lambrozo J., Thomas A.W. Magnetophosphenes perception threshold and EEG response in humans exposed to 20, 50, 60 and 100 Hz MF up to 50,000 µT. Annual Joint Meeting of the Bioelectromagnetics Society and the European Bioelectromagnetics association - BioEM2015, Asilomar, US, June 14th - 19th 2015.


Legros A., Corbacio M., Davarpanah Jazi S., Modolo J., Thomas A.W. Acute effects of a 60 Hz magnetic field of up to 100 mT on human neuromotor control: an EEG/EMG/tremor study. Annual Joint Meeting of the Bioelectromagnetics Society and the European Bioelectromagnetics association - BioEM2015, Asilomar, US, June 14th - 19th 2015.


Keenliside L., Modolo J., Thomas A.W., Legros A. Creating an ELF Magnetic Field System Over 50mT for Human Whole Head Threshold Studies. Annual Joint Meeting of the Bioelectromagnetics Society and the European Bioelectromagnetics association - BioEM2015, Asilomar, US, June 14th - 19th 2015


Camera F., Monica C.D., Legros A., Modolo J., Paffi A., Apollonio F., Liberti M. Retinal rods modeling for electric field microdosimetry. COST EMF-MED, Workshop on EMF Interaction with excitable tissues, Madrid, Spain, March 6th, 2015. 


Legros A., Modolo J., Goulet D., Plante M., Souques M., Deschamps F., Ostiguy G., Lambrozo J., Thomas A.W. Human magnetophosphene perception and EEG response to 50 and 60 Hz magnetic stimuli up to 50 mT.  1st International Brain Stimulation Conference, Singapore, 2nd – 4th March, 2015. 


Legros A., Modolo J., Goulet D., Plante M., Souques M., Deschamps F., Ostiguy G., Lambrozo J., Thomas A.W. Magnetophophene perception and EEG response in humans exposed to 50 and 60 Hz magnetic fields of up to 50 mT.  8th International Workshop on Biological Effects of Electromagnetic Fields - IWBEEMF, Varna, Bulgaria, September 21th - 26th 2014.


Modolo J., Goulet D., Plante M., Souques M., Deschamps F., Ostiguy G., Lambrozo J., Thomas A.W. Legros A. Effects of 50 and 60 Hz magnetic field exposure up to 7.6 mT on humans assessed using simultaneous EEG/fMRI.  8th International Workshop on Biological Effects of Electromagnetic Fields - IWBEEMF, Varna, Bulgaria, September 21th - 26th 2014.


Legros A., Modolo J., Goulet D., Plante M., Souques M., Deschamps F., Ostiguy G., Lambrozo J., Thomas A.W. Exemple d’effet biophysique direct dans le domaine des extrêmement basses fréquences: la perception de magnétophosphènes. Annual meeting of the Société Française de Radioprotection (SFRP) - Effets biologiques et sanitaires des rayonnements non ionisants. Limoge, France, October 16th 2014.


Legros A., Modolo J., Goulet D., Plante M., Souques M., Deschamps F., Ostiguy G., Lambrozo J., Thomas A.W. Threshold for magnetophosphenes perception and EEG response in humans exposed to 50 and 60 Hz MF up to 50,000 µT. Annual Joint Meeting of the Bioelectromagnetics Society and the European Bioelectromagnetics association - BioEM2014, Cape Town, South Africa, June 8th - 13th 2014.


Modolo J., Goulet D., Plante M., Souques M., Deschamps F., Ostiguy G., R. Paquin, Lambrozo J., Thomas A.W., Legros A. Assessment of 60 Hz MF exposure up to 7.6 mT on human brain activity: a simultaneous EEG/fMRI study. Annual Joint Meeting of the Bioelectromagnetics Society and the European Bioelectromagnetics association - BioEM2014, Cape Town, South Africa, June 8th - 13th 2014.


Legros A., Modolo J., Goulet D., Plante M., Souques M., Deschamps F., Ostiguy G., Lambrozo J., Thomas A.W. Magnetophophene perception and EEG response in humans exposed to 50 and 60 Hz magnetic fields of up to 50 mT.  5th International Conference on Electromagnetic Fields, Health and Environment - EHE2014, Porto, Portugal, April 24th - 26th 2014. Abstract Available.


Legros, A. Example of direct biophysical effects in the ELF range/Exemple d’effets biophysiques directs dans la gamme des ELF. Invited presentation to the seminar of the French Society of Environmental Health (SFSE)  - "The occupational health professionals and the exposures to electromagnetic fields (EMF): what about the Directive 2013/35/EU", Paris, France, April 2014.


Modolo J., Thomas A.W., Legros A. Mechanism-based modeling of time-varying magnetic fields effects on cortical activity. 23rd Annual Meeting of the Organization for Computational Neurosciences, July 26-31, Québec City, 2014.


Modolo J., Benquet P., Legros A., Wendling F. Contribution of synaptic plasticity processes at the onset of seizures: insights from computational modeling. Annual Meeting of the American Epilepsy Society, December 6-10, Washington DC, USA 2013.


Legros A., Modolo J., Goulet D., Plante M., Souques M., Deschamps F., Ostiguy G., Mezei G., Lambrozo J., Thomas A.W. Magnetophophene perception and associated neurophysiological responses of the human central nervous system exposed to 50 and 60 Hz magnetic fields of up to 50 mT. CIGRE EMF International colloquium, Nara, Japan, October 14th - 18th 2013. Abstract Available 


Legros A., Modolo J., Goulet D., Plante M., Souques M., Deschamps F., Ostiguy G., Mezei G., Lambrozo J., Thomas A.W. Preliminary data on human central nervous system exposed to 50 and 60 Hz magnetic fields of up to 50 mT and magnetophosphenes. Joint Meeting of the European Bioelectromagnetics Association and of the Bioelectromagnetics Society (BioEM 2013), Thessaloniki, Greece, June 10th – 14th 2013.


Modolo J., Thomas A. W., Legros A. Evaluation of 60 Hz effects thresholds on the EEG using biophysical modeling. Joint Meeting of the European Bioelectromagnetics Association and of the Bioelectromagnetics Society (BioEM 2013), Thessaloniki, Greece, June 10th – 14th 2013. 


Keenliside L., Legros A., Modolo J., Thomas, A. Apparatus for Human ELF Exposure at 50 mT. Joint Meeting of the European Bioelectromagnetics Association and of the Bioelectromagnetics Society (BioEM 2013), Thessaloniki, Greece, June 10th – 14th 2013.


Legros A., Modolo J., Goulet D., Plante M., Souques M., Deschamps F., Prato F., Lambrozo J., Thomas A.W. Threshold for a systematic neurophysiological response to 50 and 60 Hz magnetic fields of up to 50 milliTesla. 34th meeting of the Bioelectromagnetics Society, Brisbane, Australia, June 17-22nd 2012.  


Modolo J., Thomas A. W., Legros A. Changes in EEG activity during deep brain stimulation support antidromic activation of cortical neurons in a biophysical model. Movement Disorders Society 16th International Congress of Parkinson's disease and Movement Disorders, Dublin, June 17-21st 2012.


Legros A., Modolo J., Goulet D., Plante M., Souques M., Deschamps F., Prato F., Lambrozo J., Thomas A.W. Magnetophosphenes and associated brain activation: a study protocol in humans exposed to up to 50 milliTesla 50/60 Hz magnetic fields. ICNIRP Workshop, Edinburgh, May 9-11th 2012.


Legros A., Corbacio M., Miller J., Modolo J., Juen N., Goulet D., Lambrozo J., Plante M., Souques M., Prato F.S., Thomas A. W. From Behavioral Monitoring to Functional Brain Imaging: Impact of a 60 Hz Magnetic Field at 1.8, 3 and up to 50 mT in Humans. European Bioelectromagnetics Association international congress, Rome, Italy, February 21-24th, 2011. 


Legros A., Miller J., Modolo J., Corbacio M., Robertson J., Cates J., Goulet D., Lambrozo J., Plante M., Souques M., Prato F.S., Thomas A.W. Modulation de l’activité cérébrale pendant une tâche de tapping après exposition à un champ magnétique de 3000 microTesla à 60 Hz. Journée scientifique Effets biologiques et sanitaires des Rayonnements Non Ionisants organisée par la Société Française de Radioprotection. Paris, France, January 24th 2011.